Muneeb Yusuf
University of Rochester Medical Center
Biography:
Abstract:
CASE REPORT
We hereby report a case of 71 year Female who was previously known to have bronchial asthma, hypertension, ischemic heart disease and was diagnosed as a case of Hepatitis C positive on PCR 30 years before. She was known to have chronic lymphocytic Leukemia in 2012 which converted to marginal zone Lymphoma. She presented with lower limb edema in January 2023 and renal biopsy was done which revealed membranoproliferative glomerulonephritis Type 1. There is no study in the past which has observed the association between all the above mentioned diseases in one patient.
Several Investigations which include Hepatitis C PCR, Computed Tomography Scan of chest abdomen and Renal Biopsy were done for diagnosis and follow up of the progression of disease.
Patient received treatment rutaximab, steroids for treatment of marginal zone lymphoma. There was 50 % improvement of enlarged lymphadenopathy. Patient received ribavirin treatment for Hepatitis C with high viral load and decompensated liver disease and is under remission. Patient renal biopsy showed global endocapillary projection, mesangial hypercellularity with increased capillary wall thickness. Mild leukocytic infiltrate identified as well as rare intracapillary protein thrombosis. Mild interstitial fibrosis and features consistent with Membranoproliferative Glomerulonephrits Type 1. Patient was given conservative treatment such as antihypertensive medications and diuretics.